Trends in Mass Spectrometry

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About Course

This course will covers the more recent trends and research modalities in Mass Spectrometry. In fact the current trends in mass spectrometers is undoubtedly more sensitive, more selective, and allow higher throughput than those of the recent past. The analysis of complex mixtures from the drug design and discovery processes, as well as proteomics, demands improvements in these areas. Commercial manufacturers have enhanced instrument sensitivity by opening the atmosphere-to-vacuum apertures with associated increases in the vacuum pumping capacity. The quadrupoles themselves have, however, remained relatively unchanged, although some recent instruments have been equipped with ring guide collision cells.

 

 

What Will You Learn?

  • How to operate LC-MS and LC-QTOF.
  • Basics Concept of mass spectrometry and its instrumentation.
  • How to design research proposal for mass spectrometry based research project.

Course Content

Basic Concepts in Mass
Mass spectrometry is a powerful analytical technique used to quantify known materials, to identify unknown compounds within a sample, and to elucidate the structure and chemical properties of different molecules. The complete process involves the conversion of the sample into gaseous ions, with or without fragmentation, which are then characterized by their mass to charge ratios (m/z) and relative abundances.

Tandem Mass Spectrometry (LC-MS/MS)
Tandem mass spectrometry or MS/MS involves two stages of mass analysis separated by a reaction, or fragmentation, step. The most important advantage of MS/MS is the reduction of “chemical noise” due to the high specificity of the instrument.

Professional Skills in Mass Spectrometry

Scope of Current Research in LC-MS/MS

“LC-QTOF” Vs “LC-MS”

Future of LC-MS and LC-QTOF

Your Research Proposal for Clinical Application of Advanced Mass Spectrometry

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